Beyond intestinal soap—bile acids in metabolic control

  title={Beyond intestinal soap—bile acids in metabolic control},
  author={Folkert Kuipers and Vincent W. Bloks and Albert K. Groen},
  journal={Nature Reviews Endocrinology},
Over the past decade, it has become apparent that bile acids are involved in a host of activities beyond their classic functions in bile formation and fat absorption. The identification of the farnesoid X receptor (FXR) as a nuclear receptor directly activated by bile acids and the discovery that bile acids are also ligands for the membrane-bound, G-protein coupled bile acid receptor 1 (also known as TGR5) have opened new avenues of research. Both FXR and TGR5 regulate various elements of… CONTINUE READING
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