Beyond indigestion: emerging roles for lysosome-based signaling in human disease.

@article{Ferguson2015BeyondIE,
  title={Beyond indigestion: emerging roles for lysosome-based signaling in human disease.},
  author={Shawn M Ferguson},
  journal={Current opinion in cell biology},
  year={2015},
  volume={35},
  pages={59-68}
}
Lysosomes are becoming increasingly recognized as a hub that integrates diverse signals in order to control multiple aspects of cell physiology. This is illustrated by the discovery of a growing number of lysosome-localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT/TFE transcription factors (MITF, TFEB and TFE3) as proteins that shuttle between lysosomes and the nucleus to elicit a… CONTINUE READING

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This is illustrated by the discovery of a growing number of lysosome - localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT / TFE transcription factors ( MITF , TFEB and TFE3 ) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status .
This is illustrated by the discovery of a growing number of lysosome - localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT / TFE transcription factors ( MITF , TFEB and TFE3 ) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status .
Lysosomes are becoming increasingly recognized as a hub that integrates diverse signals in order to control multiple aspects of cell physiology .
Lysosomes are becoming increasingly recognized as a hub that integrates diverse signals in order to control multiple aspects of cell physiology .
Transcription, GeneticProcess involves geneTFEB gene
This is illustrated by the discovery of a growing number of lysosome - localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT / TFE transcription factors ( MITF , TFEB and TFE3 ) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status .
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