Beyond heritability: improving discoverability in imaging genetics.

@article{Fan2018BeyondHI,
  title={Beyond heritability: improving discoverability in imaging genetics.},
  author={Chun Chieh Fan and Olav B. Smeland and Andrew Joseph Schork and Chi-Hua Chen and Dominic Holland and Min-Tzu Lo and V S Sundar and Oleksandr Frei and Terry L. Jernigan and Ole Andreas Andreassen and Anders M. Dale},
  journal={Human molecular genetics},
  year={2018},
  volume={27 R1},
  pages={
          R22-R28
        }
}
Structural neuroimaging measures based on magnetic resonance imaging have been at the forefront of imaging genetics. Global efforts to ensure homogeneity of measurements across study sites have enabled large-scale imaging genetic projects, accumulating nearly 50K samples for genome-wide association studies (GWAS). However, not many novel genetic variants have been identified by these GWAS, despite the high heritability of structural neuroimaging measures. Here, we discuss the limitations of… 

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