Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.

@article{Unthan2014BeyondGR,
  title={Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.},
  author={Simon Unthan and Alexander Gr{\"u}nberger and Jan van Ooyen and Jochem Gaetgens and Johanna Heinrich and Nicole Paczia and Wolfgang Wiechert and Dietrich Kohlheyer and Stephan Noack},
  journal={Biotechnology and bioengineering},
  year={2014},
  volume={111 2},
  pages={359-71}
}
In a former study we showed that Corynebacterium glutamicum grows much faster in defined CGXII glucose medium when growth was initiated in highly diluted environments [Grünberger et al. (2013b) Biotechnol Bioeng]. Here we studied the batch growth of C. glutamicum in CGXII at a comparable low starting biomass concentration of OD ≈ 0.005 in more detail. During bioreactor cultivations a bi-phasic growth behavior with changing growth rates was observed. Initially the culture grew with μˆ=0.61±0.02… CONTINUE READING

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