Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

@inproceedings{ODonnell2017BeyondEI,
  title={Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders},
  author={Cian O'Donnell and J. Tiago Gonçalves and Carlos Portera-Cailliau and Terrence J. Sejnowski},
  booktitle={eLife},
  year={2017}
}
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca2+ imaging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance… CONTINUE READING
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