Beyond directed ortho metalation: ruthenium-catalyzed amide-directed C(Ar)-N activation/C-C coupling reaction of anthranilamides with organoboronates.

@article{Zhao2014BeyondDO,
  title={Beyond directed ortho metalation: ruthenium-catalyzed amide-directed C(Ar)-N activation/C-C coupling reaction of anthranilamides with organoboronates.},
  author={Yigang Zhao and Victor Snieckus},
  journal={Organic letters},
  year={2014},
  volume={16 12},
  pages={3200-3}
}
A new, catalytic, and general methodology for the synthesis of biaryls and heterobiaryls by the cross coupling of anthranilamide derivatives (o-NMe2 benzamides) with aryl boroneopentylates is described. The reaction proceeds under catalytic RuH2(CO)(PPh3)3 conditions driven by the activation of the unreactive C-N bond by amide directing group (DG)-Ru… CONTINUE READING