Beyond de novo protein design--de novo design of non-natural folded oligomers.

@article{Cheng2004BeyondDN,
  title={Beyond de novo protein design--de novo design of non-natural folded oligomers.},
  author={Richard P. Cheng},
  journal={Current opinion in structural biology},
  year={2004},
  volume={14 4},
  pages={512-20}
}
The mystery of how a protein sequence specifies a unique structure has intrigued chemists, leading to the design and study of foldamers, non-natural oligomeric molecules that adopt well-defined structures. Recently, the sequence specificity of the various regular repeating structures has been revealed for bioinspired foldamers and such foldamers have been created to adopt helical bundle tertiary structures. One major strategy for the generation of abiotic foldamers has involved molecular design… CONTINUE READING