Beyond complete genomes: from sequence to structure and function.

@article{Koonin1998BeyondCG,
  title={Beyond complete genomes: from sequence to structure and function.},
  author={Eugene V. Koonin and Roman L. Tatusov and Michael Y. Galperin},
  journal={Current opinion in structural biology},
  year={1998},
  volume={8 3},
  pages={
          355-63
        }
}
Computer analysis of complete prokaryotic genomes shows that microbial proteins are in general highly conserved--approximately 70% of them contain ancient conserved regions. This allows us to delineate families of orthologs across a wide phylogenetic range and, in many cases, predict protein functions with considerable precision. Sequence database searches using newly developed, sensitive algorithms result in the unification of such orthologous families into larger superfamilies sharing common… CONTINUE READING
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