Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa.

@article{Bloland1993BeyondCI,
  title={Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa.},
  author={Peter B. Bloland and Eve M Lackritz and Peter N. Kazembe and J B O Were and Richard S Steketee and C C Campbell},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 4},
  pages={
          932-7
        }
}
Emphasis on retaining chloroquine as the first-line therapy for Plasmodium falciparum infections in most of sub-Saharan Africa for as long as it remains effective has resulted in widespread reliance on chloroquine in areas where it can have little effect on P. falciparum parasitemia. To address this issue, clinical, parasitologic, and hematologic responses to chloroquine or pyrimethamine/sulfadoxine treatment were assessed among very young children in Malawi (n = 153) and Kenya (n = 73). The… CONTINUE READING
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