Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors

@inproceedings{Beaulieu2011BeyondCT,
  title={Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors},
  author={J E Beaulieu and Thomas Del’Guidice and Tatyana D. Sotnikova and Morgane Lemasson and Raul R Gainetdinov},
  booktitle={Front. Mol. Neurosci.},
  year={2011}
}
Brain dopamine receptors have been preferred targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can engage also in Akt/GSK3 signaling cascade provided a new framework to understand intracellular signaling mechanisms involved in dopamine-related behaviors and pathologies. Here we review a recent progress in understanding the role of Akt, GSK3, and related… CONTINUE READING

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