Beyond blood brain barrier breakdown – in vivo detection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI

@article{Tysiak2009BeyondBB,
  title={Beyond blood brain barrier breakdown – in vivo detection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI},
  author={Eva Tysiak and Patrick Asbach and Orhan Aktas and Helmar Waiczies and Maureen Smyth and J{\"o}rg Schnorr and Matthias Taupitz and Jens Wuerfel},
  journal={Journal of Neuroinflammation},
  year={2009},
  volume={6},
  pages={20 - 20}
}
Gadopentate dimeglumine (Gd-DTPA) enhanced magnetic resonance imaging (MRI) is widely applied for the visualization of blood brain barrier (BBB) breakdown in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Recently, the potential of magnetic nanoparticles to detect macrophage infiltration by MRI was demonstrated. We here investigated a new class of very small superparamagnetic iron oxide particles (VSOP) as novel contrast medium in murine adoptive… CONTINUE READING
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