Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study.

@article{Simpson2010BeyondAM,
  title={Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study.},
  author={Angela Simpson and Vincent Yan Fu Tan and John Winn and Markus Svens{\'e}n and Christopher M. Bishop and David Heckerman and Iain E. Buchan and Adnan Custovic},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={181 11},
  pages={
          1200-6
        }
}
RATIONALE The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy. OBJECTIVES To redefine the atopic phenotype by identifying latent structure within a complex dataset, taking into account the timing and type of sensitization to specific allergens, and relating these novel phenotypes to asthma. METHODS In a population-based birth… CONTINUE READING

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