Beyond antioxidant genes in the ancient Nrf2 regulatory network.

@article{Lacher2015BeyondAG,
  title={Beyond antioxidant genes in the ancient Nrf2 regulatory network.},
  author={Sarah E. Lacher and Joslynn S. Lee and Xuting Wang and Michelle R. Campbell and Douglas A. Bell and Matthew Slattery},
  journal={Free radical biology & medicine},
  year={2015},
  volume={88 Pt B},
  pages={
          452-465
        }
}
Nrf2, a basic leucine zipper transcription factor encoded by the gene NFE2L2, is a master regulator of the transcriptional response to oxidative stress. Nrf2 is structurally and functionally conserved from insects to humans, and it heterodimerizes with the small MAF transcription factors to bind a consensus DNA sequence (the antioxidant response element, or ARE) and regulate gene expression. We have used genome-wide chromatin immunoprecipitation and gene expression data to identify direct Nrf2… CONTINUE READING

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