Beyond antiangiogenesis: intratumorally injected bevacizumab plays a cisplatin-sensitizing role in squamous cell carcinomas in mice.

@article{Wang2011BeyondAI,
  title={Beyond antiangiogenesis: intratumorally injected bevacizumab plays a cisplatin-sensitizing role in squamous cell carcinomas in mice.},
  author={Yixiang Wang and Ling Wang Dong and Qingwei Bi and Xiyuan Ge and Xiaoxia Zhang and Dengcheng Wu and Jia Fu and Chengfei Zhang and Cunyu Wang and Shenglin Li},
  journal={Chemotherapy},
  year={2011},
  volume={57 3},
  pages={
          244-52
        }
}
BACKGROUND The anticancer mechanism of bevacizumab beyond antiangiogenesis remains unclear. Here, we investigated whether intratumorally injected bevacizumab could serve as an effective cisplatin sensitizer in squamous cell carcinoma (SCC) in vivo. METHODS Hela and SCC-VII experimental SCC models were established to investigate the anticancer effect of bevacizumab plus cisplatin and the underlying mechanism using immunostaining, TUNEL, and Western blot assays. RESULTS Bevacizumab-cisplatin… CONTINUE READING
BETA