Beyond Warburg effect – dual metabolic nature of cancer cells

  title={Beyond Warburg effect – dual metabolic nature of cancer cells},
  author={Jiansheng Xie and Hao Wu and Chunyan Dai and Qiangrong Pan and Zonghui Ding and Danqing Hu and Bingyan Ji and Yan Luo and Xun Hu},
  booktitle={Scientific reports},
Warburg effect is a dominant phenotype of most cancer cells. Here we show that this phenotype depends on its environment. When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a nonglycolytic phenotype, characterized by a high ratio of oxygen consumption rate over glycolytic rate, negligible lactate production and efficient incorporation of glucose carbon(s) into cellular mass. These two metabolic modes are intimately… CONTINUE READING
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