Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

@article{Sieweke2013BeyondSC,
  title={Beyond Stem Cells: Self-Renewal of Differentiated Macrophages},
  author={Michael H Sieweke and Judith E. Allen},
  journal={Science},
  year={2013},
  volume={342}
}
Background Many mature cells of the body are continuously replaced, particularly in tissues that are most exposed to the environment such as cells of the immune system. The need for new cells is driven by cellular turnover during normal tissue homeostasis and is further increased upon infection. Because differentiated cells typically withdraw from the cell cycle, replacement of mature cells is generally thought to depend on differentiation of self-renewing, tissue-specific stem cells. Until… 

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References

SHOWING 1-10 OF 102 REFERENCES

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues.

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

Most tissues develop from stem cells and precursors that undergo differentiation as their proliferative potential decreases. Mature differentiated cells rarely proliferate and are replaced at the end

Mechanisms of stem cell self-renewal.

In response to changing tissue demands, stem cells undergo changes in cell cycle status and developmental potential over time, requiring different self-renewal programs at different stages of life.

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

It is reported that combined deficiency for the transcription factors MafB and c-Maf enables extended expansion of mature monocytes and macrophages in culture without loss of differentiated phenotype and function and thus appears possible to amplify functional differentiated cells without malignant transformation or stem cell intermediates.

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

Macrophage (MØ) biology is routinely modelled in the peritoneal cavity, a vascular tissue readily infiltrated by leukocytes during inflammation. After several decades of study, no consensus has

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

It is shown that MDPs are in vivo precursors of BM and blood monocytes, and grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCS in the spleen, which develop during homeostasis from M DPs without a monocytic intermediate.

Langerhans cells arise from monocytes in vivo

It is established that CSF-1 receptor–deficient hematopoietic precursors failed to reconstitute the LC pool in inflamed skin and monocytes with high expression of the monocyte marker Gr-1 were specifically recruited to the inflamedskin, proliferated locally and differentiated into LCs.

Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation

It is shown that proliferation of both bone marrow-derived inflammatory and tissue resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation.
...