Beyond PrPres Type 1/Type 2 Dichotomy in Creutzfeldt-Jakob Disease

  title={Beyond PrPres Type 1/Type 2 Dichotomy in Creutzfeldt-Jakob Disease},
  author={Emmanuelle Uro-Coste and Herv{\'e} Cassard and St{\'e}phanie Simon and S{\'e}verine Lugan and J M Bilheude and Armand Perret-Liaudet and James W Ironside and St{\'e}phane Haik and Christelle Basset-Leobon and Caroline Lacroux and Katell Peoch' and Nathalie Streichenberger and Jan Langeveld and Mark W Head and J acques Grassi and J. J. Hauw and François Schelcher and Marie-Bernadette Delisle and Olivier Andr{\'e}oletti},
  booktitle={PLoS pathogens},
Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently subclassified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K (PK) digested abnormal prion protein (PrPres)identified on Western blotting (type 1 or type 2). These biochemically distinct PrPres types have been considered to represent potential distinct prion strains. However, since cases of CJD show co-occurrence of type 1 and type 2 PrPres in the brain, the basis of this… CONTINUE READING


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