Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway

  title={Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway},
  author={Timothy G. Lesnick and Eric J. Sorenson and J. Eric Ahlskog and John R. Henley and Lina A Shehadeh and Spyridon Spyros Papapetropoulos and Demetrius M. Maraganore},
  journal={PLoS ONE},
  pages={e98 - 240}
BACKGROUND We recently described a genomic pathway approach to study complex diseases. We demonstrated that models constructed using single nucleotide polymorphisms (SNPs) within axon guidance pathway genes were highly predictive of Parkinson disease (PD) susceptibility, survival free of PD, and age at onset of PD within two independent whole-genome association datasets. We also demonstrated that several axon guidance pathway genes represented by SNPs within our final models were differentially… CONTINUE READING


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