Beyond NMR spectra of antimicrobial peptides: dynamical images at atomic resolution and functional insights.

Abstract

There is a considerable current interest in understanding the function of antimicrobial peptides for the development of potent novel antibiotic compounds with a very high selectivity. Since their interaction with the cell membrane is the major driving force for their function, solid-state NMR spectroscopy is the unique method of choice to study these insoluble, non-crystalline, membrane-peptide complexes. Here I discuss solid-state NMR studies of antimicrobial peptides that have reported high-resolution structure, dynamics, orientation, and oligomeric states of antimicrobial peptides in a membrane environment, and also address important questions about the mechanism of action at atomic-level resolution. Increasing number of solid-state NMR applications to antimicrobial peptides are expected in the near future, as these compounds are promising candidates to overcome ever-increasing antibiotic resistance problem and are well suited for the development and applications of solid-state NMR techniques.

DOI: 10.1016/j.ssnmr.2009.03.003
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@article{Ramamoorthy2009BeyondNS, title={Beyond NMR spectra of antimicrobial peptides: dynamical images at atomic resolution and functional insights.}, author={Ayyalusamy Ramamoorthy}, journal={Solid state nuclear magnetic resonance}, year={2009}, volume={35 4}, pages={201-7} }