Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.

@article{Besancon2008BeyondNA,
  title={Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.},
  author={Elaine F Besancon and Shuzhen Guo and Josephine M Lok and M Tymianski and Eng H. Lo},
  journal={Trends in pharmacological sciences},
  year={2008},
  volume={29 5},
  pages={268-75}
}
The glutamate receptor was one of the most intensely investigated targets for neuroprotection. However, numerous clinical trials of glutamate receptor antagonists for the treatment of stroke were unsuccessful. These failures have led to pessimism in the field. But recent advances could provide hope for the future. This minireview looks beyond the traditional mechanism of glutamate-receptor-driven excitotoxicity to identify other mechanisms of ionic imbalance. These advances include findings… CONTINUE READING
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