Beyond LDL cholesterol, a new role for PCSK9.

  title={Beyond LDL cholesterol, a new role for PCSK9.},
  author={Omar N Akram and Adeline Bernier and Francine Petrides and Gida Wong and Gilles Lambert},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={30 7},
Elevated low-density lipoprotein cholesterol (LDLC) levels in the plasma is the most important causative factor of atherosclerosis and associated ischemic cardiovascular diseases. The LDL receptor (LDLR) is the preferential pathway through which LDLs are cleared from the circulation. LDLs bound to the LDLR are internalized into clathrin-coated pits and… CONTINUE READING