Beyond Dopamine: Glutamate as a Target for Future Antipsychotics

  title={Beyond Dopamine: Glutamate as a Target for Future Antipsychotics},
  author={Kyra-Verena Sendt and Giovanni Giaroli and Derek Kenneth Tracy},
  booktitle={ISRN pharmacology},
The dopamine hypothesis of schizophrenia remains the primary theoretical framework for the pharmacological treatment of the disorder. Despite various lines of evidence of dopaminergic abnormalities and reasonable efficacy of current antipsychotic medication, a significant proportion of patients show suboptimal treatment responses, poor tolerability, and a subsequent lack of treatment concordance. In recent decades, intriguing evidence for the critical involvement of other neurotransmitter… CONTINUE READING
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