Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age

  title={Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age},
  author={Samuel Baker and Pietro Biroli and Hans van Kippersluis and Stephanie von Hinke},
  journal={SSRN Electronic Journal},
Adverse conditions in early life can have consequential impacts on individuals’ health in older age. In one of the first papers on this topic, Barker and Osmond (1986) show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s. We go ‘beyond Barker’, first by showing that this relationship is robust to the inclusion of local geographic area fixed effects, but not family fixed effects. Second, we explore whether the average effects conceal… 
Gene-Environment Interplay in the Social Sciences
Nature (one’s genes) and nurture (one’s environment) jointly contribute to the formation and evolution of health and human capital over the life cycle. This complex interplay between genes and


The Dutch Hunger Winter and the developmental origins of health and disease
  • L. Schulz
  • Medicine
    Proceedings of the National Academy of Sciences
  • 2010
The Dutch Hunger Winter study provides an almost perfectly designed, although tragic, human experiment in the effects of intrauterine deprivation on subsequent adult health, and provides crucial support and fundamental insights for the growing field of the developmental origins of health and disease (DOHaD).
Developmental origins of health and disease theory in cardiology.
Long-run Health and Mortality Effects of Exposure to Universal Health Care at Birth
Findings indicate that age-specific survival rates are systematically higher among lower class individuals whose post-natal care expanded through the NHS, representing a 16% reduction in mortality by age 64.
No increased mortality in later life for cohorts born during famine.
The findings suggest that, although cohorts subjected to prolonged and extreme nutritional deprivation in utero and during infancy and early childhood suffer an immediate rise in mortality, after the crisis has passed, they carry no aftereffects that influence their survival in later life.
Developmental Origins of Health Inequality
A wide body of research has emerged, incorporating the original ‘Fetal Origins Hypothesis’ into the ‘Developmental Origins of Health and Disease’, suggesting that health inequalities are strongly correlated with many dimensions of socio-economic status; and that they tend to increase with age and carry stark intergenerational implications.
Severe Prenatal Shocks and Adolescent Health: Evidence from the Dutch Hunger Winter
It is shown that the cohorts exposed to the Dutch Hunger Winter since early gestation have a higher Body Mass Index and an increased probability of being overweight at age 18, and that this effect is partly accounted for by warfare exposure and a reduction in energy-adjusted protein intake.
Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study
Intrauterine malnutrition was not associated with glucose intolerance, dyslipidaemia, hypertension, or cardiovascular disease in adulthood, and subjects exposed to malnutrition showed evidence of endothelial dysfunction and a stronger influence of obesity on blood pressure.