Beyond BRAFV600: clinical mutation panel testing by next-generation sequencing in advanced melanoma

  title={Beyond BRAFV600: clinical mutation panel testing by next-generation sequencing in advanced melanoma},
  author={Alan E. Siroy and Genevieve Marie Boland and Den{\'a}i R. Milton and Jason Roszik and Silva Frankian and Jared Malke and Lauren E. Haydu and Victor G Prieto and Michael T Tetzlaff and Doina Ivan and Wei-Lien Wang and Carlos A Torres-Cabala and Jonathan L Curry and Sinchita Roy-Chowdhuri and Russell R. Broaddus and Asif Rashid and John Stewart and Jeffrey E Gershenwald and Rodabe N Amaria and Sapna P Patel and Nicholas E J Papadopoulos and Agop Y. Bedikian and W J Hwu and Patrick Hwu and Adi Diab and Scott E. Woodman and Kenneth D. Aldape and Rajyalakshmi Luthra and Keyur Pravinchandra Patel and Kenna R. Mills Shaw and Gordon B. Mills and John Mendelsohn and Funda Meric-Bernstam and Kevin B Kim and Mark J Routbort and Alexander J Lazar and Michael A. Davies},
  booktitle={The Journal of investigative dermatology},
The management of melanoma has evolved owing to improved understanding of its molecular drivers. To augment the current understanding of the prevalence, patterns, and associations of mutations in this disease, the results of clinical testing of 699 advanced melanoma patients using a pan-cancer next-generation sequencing (NGS) panel of hotspot regions in 46 genes were reviewed. Mutations were identified in 43 of the 46 genes on the panel. The most common mutations were BRAFV600 (36%), NRAS (21… CONTINUE READING
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