Bex1 knock out mice show altered skeletal muscle regeneration.

  title={Bex1 knock out mice show altered skeletal muscle regeneration.},
  author={Jae Hyung Koo and M Autumn Smiley and Richard M Lovering and Frank L. Margolis},
  journal={Biochemical and biophysical research communications},
  volume={363 2},
Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection… CONTINUE READING

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