Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.

@article{Dickson2007BevacizumabinducedTR,
  title={Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.},
  author={Paxton V Dickson and J. Blair Hamner and Thomas L. Sims and Charles H. Fraga and Catherine Y C Ng and Surender Rajasekeran and Nikolaus L Hagedorn and M Beth McCarville and Clinton F. Stewart and Andrew M. Davidoff},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 13},
  pages={
          3942-50
        }
}
PURPOSE Dysfunctional tumor vessels can be a significant barrier to effective cancer therapy. However, increasing evidence suggests that vascular endothelial growth factor (VEGF) inhibition can effect transient "normalization" of the tumor vasculature, thereby improving tumor perfusion and, consequently, delivery of systemic chemotherapy. We sought to examine temporal changes in tumor vascular function in response to the anti-VEGF antibody, bevacizumab. EXPERIMENTAL DESIGN Established… CONTINUE READING

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