Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells

@article{AttarSchneider2012BevacizumabAM,
  title={Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells},
  author={Oshrat Attar-Schneider and Liat Drucker and Victoria Zismanov and Shelly Tartakover-Matalon and Gloria Rashid and Michael Lishner},
  journal={Laboratory Investigation},
  year={2012},
  volume={92},
  pages={178-190}
}
Multiple myeloma (MM), a malignancy of plasma cells, remains fatal despite introduction of novel therapies, partially due to humoral factors, including vascular endothelial growth factor (VEGF), in their microenvironment. The aim of this study was to explore the efficacy of anti-VEGF treatment with bevacizumab directly on MM cells. Particular attention was directed to the affect of VEGF inhibition on protein translation initiation. Experiments were conducted on MM cells (lines, bone marrow (BM… CONTINUE READING
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