Bevacizumab and rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy.

@article{Lee2012BevacizumabAR,
  title={Bevacizumab and rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy.},
  author={Kyoung Sub Lee and Dong-Ah Ko and Eun-Soon Kim and Myoung J. Kim and Hungwon Tchah and Jae Yong Kim},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 12},
  pages={7645-53}
}
PURPOSE We investigated the effects of bevacizumab and rapamycin on central corneal opacity and apoptotic keratocyte number after photorefractive keratectomy (PRK) followed by ultraviolet B (UV-B) irradiation. METHODS A total of 60 right eyes of Sprague-Dawley rats in four groups (n = 15 each) underwent PRK ablation to 80 μm with a 3-mm zone. Sponges soaked with 0.02% mitomycin C (MMC), 2.5% bevacizumab, 0.01% rapamycin, and balanced saline solution were applied for 2 minutes to these eyes in… CONTINUE READING