Bevacizumab and Glioblastoma: Past, Present, and Future Directions

@article{Kim2018BevacizumabAG,
  title={Bevacizumab and Glioblastoma: Past, Present, and Future Directions},
  author={Michelle M. Kim and Yoshie Umemura and Denise Leung},
  journal={The Cancer Journal},
  year={2018},
  volume={24},
  pages={180–186}
}
Abstract Glioblastoma (GBM) is the most common and lethal intracranial malignancy, with few advances in treatment over the last several decades. Much excitement surrounded the initial approval for bevacizumab for recurrent GBM, given the marked radiographic responses and improvement in progression-free survival observed in early studies. However, phase III studies have failed to demonstrate an overall survival advantage with the use of this agent. An overview of the mechanism of action and… 

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