Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.

@article{Cesca2016BevacizumabInducedIO,
  title={Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.},
  author={Marta Cesca and Lavinia Morosi and Alexander Berndt and Ilaria Fuso Nerini and Roberta Frapolli and Petra Richter and Alessandra Decio and Olaf Dirsch and Edoardo Micotti and Silvia Giordano and Maurizio D'Incalci and Enrico Davoli and Massimo Zucchetti and Raffaella Giavazzi},
  journal={Molecular cancer therapeutics},
  year={2016},
  volume={15 1},
  pages={125-35}
}
The antitumor activity of angiogenesis inhibitors is reinforced in combination with chemotherapy. It is debated whether this potentiation is related to a better drug delivery to the tumor due to the antiangiogenic effects on tumor vessel phenotype and functionality. We addressed this question by combining bevacizumab with paclitaxel on A2780-1A9 ovarian carcinoma and HT-29 colon carcinoma transplanted ectopically in the subcutis of nude mice and on A2780-1A9 and IGROV1 ovarian carcinoma… CONTINUE READING
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