Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies.


OBJECTIVE To review the pharmacology, pharmacokinetics, and pivotal clinical trials for bevacizumab, emphasizing its use in colorectal cancer. DATA SOURCES A PubMed/MEDLINE search was conducted (1966-April 2004) using the following terms: bevacizumab, Avastin, anti-VEGF, anti-angiogenesis, and colorectal cancer. Additional data sources included meeting… (More)


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