Between molecules and morphology. Extracellular matrix and creation of vascular form.

@article{Vernon1995BetweenMA,
  title={Between molecules and morphology. Extracellular matrix and creation of vascular form.},
  author={Robert B. Vernon and Elizabeth Sage},
  journal={The American journal of pathology},
  year={1995},
  volume={147 4},
  pages={873-83}
}
In response to an angiogenic stimulus, ECs initiate programs of gene expression that result in the quantitative alteration of gene products within nuclear, cytoplasmic, cell surface, and extracellular compartments. During the formation of new microvasculature, patterns of molecular expression among individual ECs must direct the creation of complex, multicellular morphologies in two and three dimensions. Studies in vitro indicate that cell-generated forces of tension can organize ECM into… CONTINUE READING

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