Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis.

Abstract

The possible protective effect of betulinic acid on renal ischemia/reperfusion (I/R) injury was studied. Wistar Albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Betulinic acid (250 mg/kg, i.p.) or saline was administered at 30 min prior to ischemia and immediately before the… (More)
DOI: 10.1002/ptr.2929

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