Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.

@article{Fulda2000BetulinicAI,
  title={Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.},
  author={Simone Fulda and K. M. Debatin},
  journal={Medical and pediatric oncology},
  year={2000},
  volume={35 6},
  pages={616-8}
}
BACKGROUND AND PROCEDURE We identified BetA as a new cytotoxic agent active against neuroectodermal tumor cells including neuroblastoma, medulloblastoma, glioblastoma and Ewing sarcoma cells, representing the most common solid tumors of childhood. RESULTS BetA induced apoptosis by a direct effect on mitochondria independent of accumulation of wild-type p53 protein and independent of death-inducing ligand/receptor systems such as CD95. Mitochondrial perturbations on treatment with BetA… CONTINUE READING
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