Betulinic acid: A new cytotoxic compound against malignant head and neck cancer cells

@article{Thurnher2003BetulinicAA,
  title={Betulinic acid: A new cytotoxic compound against malignant head and neck cancer cells},
  author={Dietmar Thurnher and Dritan Turhani and Martina Pelzmann and Bettina Wannemacher and Birgit Knerer and Michael Formanek and Volker Wacheck and Edgar Selzer},
  journal={Head \& Neck},
  year={2003},
  volume={25}
}
A new compound, betulinic acid, has been found to be cytotoxic against a variety of tumor cells originating from the neural crest. Its efficacy against head and neck squamous cellular carcinoma cell lines has so far not been tested. 
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A novel semi‐synthetic betulinic acid‐derived drug candidate well suited for further clinical development is presented.
Betulinic Acid for Cancer Treatment and Prevention
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Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail.
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In-vitro studies have identified this agent as potently effective against a wide variety of cancer cells, also those derived from therapy-resistant and refractory tumors, whereas it has been found to be relatively nontoxic for healthy cells.
Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines
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Comparison of cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma and human pancreatic carcinoma cell lines shows significant differences in sensitivity between cell lines depending on the compound used, and suggests that both betulin And betulin can be considered as a promising leads in the treatment of cancer.
Betulinic Acid a Radiosensitizer in Head and Neck Squamous Cell Carcinoma Cell Lines
TLDR
It could be shown that betulinic acid alone inhibits cell survival, affects cell survival additively in combination with irradiation and decreases clonogenic survival in both cell lines when applied alone.
Betulinic acid: a natural product with anticancer activity.
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In contrast to the potent cytotoxicity of BA against a variety of cancer types, nonmalignant cells and normal tissue remained relatively resistant to BA, indicating a therapeutic window.
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Recent advances in research into anticancer activity of BetA are discussed, including relevant modes of delivery, and the agent's therapeutic efficacy, mechanism of action, and future perspective as a pipeline anticancer drug.
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.
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