Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

@inproceedings{oica2014BetulinicAI,
  title={Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells},
  author={Codruţa Şoica and Corina Danciu and Germaine Savoiu-Balint and Florin Borcan and Rita Ambrus and Istv{\'a}n Zupk{\'o} and Florina Bojin and Dorina Coricovac and Sorina Ciurlea and Stefana Avram and Cristina Adriana Dehelean and Teodora Olariu and Petru Matusz},
  booktitle={International journal of molecular sciences},
  year={2014}
}
Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell… CONTINUE READING
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