Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice

@inproceedings{Zhou2017BetulinFH,
  title={Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice},
  author={Yong-qin Zhou and Xiu-fang Weng and Rui Dou and Xiao-sheng Tan and Tian-tian Zhang and Jin-bo Fang and Xiong-wen Wu},
  booktitle={Acta Pharmacologica Sinica},
  year={2017}
}
Hedyotis hedyotidea has been used in traditional Chinese medicine for the treatment of autoimmune diseases. However, the mechanisms underlying for the effect remain unknown. We previously showed that, among 11 compounds extracted from H hedyotidea, betulin produced the strongest suppressive effect on T cell activation. Here, we examined the hepatoprotective effects of betulin against acute autoimmune hepatitis in mice and the mechanisms underlying the effects. Freshly isolated mouse splenocytes… CONTINUE READING
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