Betting on Cilia

  title={Betting on Cilia},
  author={Gretchen Vogel},
  pages={216 - 218}
  • G. Vogel
  • Published 14 October 2005
  • Biology
  • Science
With help from a single-celled alga, scientists are learning that cilia play unexpectedly crucial roles in human development and disease. 
Cilium-generated signaling: a cellular GPS?
  • T. Benzing, G. Walz
  • Medicine, Biology
  • Current opinion in nephrology and hypertension
  • 2006
A novel concept and testable hypothesis for the function of cilia in vertebrates is emerging: cilia may act as a cellular positioning device to allow subcellular asymmetry and polarization of the cells within the plane of the epithelium to develop and maintain regular arrays of cells such as kidney tubes. Expand
Select Acetophenones Modulate Flagellar Motility in Chlamydomonas
Four acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, suggesting interference with activity of flagellar proteins and control of flagllar dominance. Expand
RING box protein-1 gene involved in flagellar disassembly of Dunaliella salina
The results indicated that RBX1 responded to flagellar disassembly of D. salina and was expressed in Escherichia coli BL21 and was purified and characterized. Expand
Regulation of mammalian ciliary beating.
  • M. Salathe
  • Biology, Medicine
  • Annual review of physiology
  • 2007
The regulation mechanisms of ciliary beat regulation by intracellular second messengers remain somewhat controversial, favoring an immediate, direct action of calcium on ciliary beating and a second cyclic nucleotide-dependent phase. Expand
An Integrative Computational Model of Multiciliary Beating
This computational model allows us to predict the geometry of beating, along with the detailed description of the time-dependent flow field both near and away from the cilia, and shows that synchrony and metachrony can, indeed, arise from hydrodynamic coupling. Expand
Tumbling for Stealth?
Polin et al. (4) show how synchronization of the flagella in Chlamydomonas reinhardtii governs the movement of this green alga through water, a key determinant of its ecological fitness. Expand
Force generation and dynamics of individual cilia under external loading.
By applying a quasistatic force model, it is deduced that axoneme stiffness is dominated by the rigidity of the microtubules, and that cilia can exert 62 +/- 18 pN of force at the tip via the generation of 5.6 +/- 1.6 pN/dynein head. Expand
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives.
The evidence that collectrin binds to SNARE complex by interacting with snapin suggests the presence of uncharacterized physiological functions of collectrin, the new therapeutic target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria. Expand
Aberrant planar cell polarity induced by urinary tract obstruction.
The results indicate that aberrant PCP may contribute to cyst-like tubular dilatation in obstructive uropathy, and Interestingly, the orientation of cell division, localization of aPKC, and Fz3 expression return to normal when obstruction is relieved, which suggest a role of normal PCP signaling in tubular repair. Expand
Analysis of the orientation of primary cilia in growth plate cartilage: a mathematical method based on multiphoton microscopical images.
The application of classical mathematical methods are reported on to develop an algorithm that addresses the particular challenges relative to the assessment of the orientation of the primary cilium in growth plate cartilage, based on image analysis of optical sections visualized by multiphoton microscopy. Expand