Better prediction of sub-cellular localization by combining evolutionary and structural information.

@article{Nair2003BetterPO,
  title={Better prediction of sub-cellular localization by combining evolutionary and structural information.},
  author={Rajesh Nair and Burkhard Rost},
  journal={Proteins},
  year={2003},
  volume={53 4},
  pages={917-30}
}
The native sub-cellular compartment of a protein is one aspect of its function. Thus, predicting localization is an important step toward predicting function. Short zip code-like sequence fragments regulate some of the shuttling between compartments. Cataloguing and predicting such motifs is the most accurate means of determining localization in silico. However, only few motifs are currently known, and not all the trafficking appears regulated in this way. The amino acid composition of a… CONTINUE READING
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