Better allele-level matching improves transplant-related mortality after double cord blood transplantation.

@article{Oran2015BetterAM,
  title={Better allele-level matching improves transplant-related mortality after double cord blood transplantation.},
  author={Bet{\"u}l Oran and Kai Cao and Rima Saliba and K Rezvani and Marcos de Lima and Sairah Ahmed and Chitra M Hosing and Uday R Popat and Yudith Carmazzi and Partow Kebriaei and Yago L. Nieto and Gabriela Rond{\'o}n and Dana Willis and Nina Shah and Simrit Parmar and Amanda L Olson and Brandt Moore and D. W. Marin and Rohtesh S. Mehta and Marcelo An{\'i}bal Fern{\'a}ndez-Vi{\~n}a and Richard E. Champlin and Elizabeth J Shpall},
  journal={Haematologica},
  year={2015},
  volume={100 10},
  pages={1361-70}
}
Cord blood transplant requires less stringent human leukocyte antigen matching than unrelated donors. In 133 patients with hematologic malignancies who engrafted after double cord blood transplantation with a dominant unit, we studied the effect of high resolution testing at 4 loci (-A, -B, -C, -DRB1) for its impact on 2-year transplant-related mortality. Ten percent of the dominant cord blood units were matched at 7-8/8 alleles using HLA-A, -B, -C, and -DRB1; 25% were matched at 6/8, 40% at 5… CONTINUE READING

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