Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer.

@article{Raedle2001BethesdaGR,
  title={Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer.},
  author={Jochen Raedle and Jorg Trojan and Angela Brieger and Nina Weber and Desiree Schaefer and Guido Plotz and Elisabeth Staib-Sebler and Susanne Kriener and Matthias Lorenz and Stephan Zeuzem},
  journal={Annals of internal medicine},
  year={2001},
  volume={135 8 Pt 1},
  pages={566-76}
}
Hereditary nonpolyposis colorectal cancer (HNPCC) is a common, inherited cancer syndrome associated with an increased lifetime risk for cancer, predominantly colorectal and endometrial cancer (1). This familial cancer syndrome is frequently caused by germline mutations in MLH1 and MSH2; other DNA mismatch repair genes (MSH6, PMS1, PMS2) are rarely affected (24). Tumors in mutation carriers typically exhibit microsatellite instability, a characteristic phenotype that is caused by expansions or… CONTINUE READING

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