Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats.

@article{Rudoy2007BetaxololAS,
  title={Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats.},
  author={Carla A. Rudoy and Elisabeth J. Van Bockstaele},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2007},
  volume={31 5},
  pages={1119-29}
}
BACKGROUND Anxiety has been indicated as one of the main symptoms of the cocaine withdrawal syndrome in human addicts and severe anxiety during withdrawal may potentially contribute to relapse. As alterations in noradrenergic transmission in limbic areas underlie withdrawal symptomatology for many drugs of abuse, the present study sought to determine the effect of cocaine withdrawal on beta-adrenergic receptor (beta(1) and beta(2)) expression in the amygdala. METHODS Male Sprague Dawley rats… CONTINUE READING

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