• Corpus ID: 29921535

Betanin ameliorates isoproterenol-induced acute myocardial infarction through iNOS , inflammation , oxidative stress-myeloperoxidase / low-density lipoprotein in rat

@inproceedings{Yang2016BetaninAI,
  title={Betanin ameliorates isoproterenol-induced acute myocardial infarction through iNOS , inflammation , oxidative stress-myeloperoxidase / low-density lipoprotein in rat},
  author={Bo Yang and Feng Cao and Hua Zhao and Jian Zhang and Bo Jiang and Qing Wu},
  year={2016}
}
The present study aimed to investigate betanin ameliorates isoproterenol-induced AMI through iNOS, inflammation, oxidative stress-myeloperoxidase (MPO)/low-density lipoprotein (LDL) in rat. Cardiovascular diseases CVD is considered as the first killer of human beings. The major pathogenesis of malignant cardiovascular events is chronic heart failure caused by acute myocardial infarction (AMI). Adult male Sprague-Dawley (SD) rat was induced using 100 mg/kg of isoproterenol and used for proving… 

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References

SHOWING 1-10 OF 27 REFERENCES

Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat.

Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans.

TLDR
Reduction in ONOO--induced nitro-oxidative stress subsequent to the inhibition of iNOS represents a major mechanism whereby postcon confers cardioprotection in vivo.

Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins

TLDR
This study shows that betanin, a phytochemical of the betalain class, inhibits the production of lipid hydroperoxides in human LDL submitted to a MPO/nitrite-induced oxidation.

Urinary 1-Hydroxypyrene is Associated with Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction

TLDR
The findings indicate that the exposure to pyrenes was associated to lipid damage and alterations of endogenous and exogenous antioxidants, demonstrating that PAHs contribute to oxidative stress and are associated to acute myocardial infarction.

Cardioprotective Effects of Essential Oil of Lavandula angustifolia on Isoproterenol-induced Acute Myocardial Infarction in Rat

TLDR
The results demonstrated that L. angustifolia protects myocardium against isoproterenol-induced MI that it could be related to its antioxidant properties.

Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia

TLDR
It is indicated that betanin attenuates paraquat-induced acute lung injury possibly via antioxidant and anti-inflammatory mechanisms and the potential for using betan in as an auxilliary therapy for ALI should be explored further.

Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment

TLDR
The inflammatory protein myeloperoxidase is present, active and mechanistically poised to participate in the initiation and progression of cardiovascular disease, and this leukocyte protein may have clinical utility in risk stratification for cardiovascular disease status and outcomes.

Paraoxonase gene Q192R & L55M polymorphisms in Indians with acute myocardial infarction & association with oxidized low density lipoprotein.

TLDR
No correlation of PON 192 or 55 polymorphism was found with oxidized LDL suggesting that presence of other antioxidant factors may be of equal importance in preventing LDL oxidation, and the present study looks at PON192 and55 polymorphism among hospitalized Asian Indian patients with myocardial infarction and their association with circulating oxidized cholesterol and antioxidant status.

Early effect of pravastatin on serum soluble CD40L, matrix metalloproteinase-9, and C-reactive protein in patients with acute myocardial infarction.

TLDR
The effect of a low dose of statin on inflammatory markers in patients with acute myocardial infarction in the first 3 days of treatment before changes in serum lipids could be detected is studied.