Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.

@article{Wang2010BetaineIA,
  title={Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.},
  author={Zhigang Wang and Tong Yao and Maria Pini and Zhanxiang 3 Zhou and Giamila Fantuzzi and Zhenyuan Song},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2010},
  volume={298 5},
  pages={
          G634-42
        }
}
Adipose tissue dysfunction, featured by insulin resistance and/or dysregulated adipokine production, plays a central role not only in disease initiation but also in the progression to nonalcoholic steatohepatitis and cirrhosis. Promising beneficial effects of betaine supplementation on nonalcoholic fatty liver disease (NAFLD) have been reported in both clinical investigations and experimental studies; however, data related to betaine therapy in NAFLD are still limited. In this study, we… CONTINUE READING

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Betaine reduced insulin resistance and hepatic steatosis, and augments hepatic insulin signaling, in an animal model of NAFLD (Abstract)

  • E Kathirvel, K Morgan, SW French, TR. Morgan
  • Hepatology 48:
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