Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?

  title={Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?},
  author={Mar{\'i}a Angeles Pajares and Dolores P{\'e}rez-Sala},
  journal={Cellular and Molecular Life Sciences CMLS},
Betaine homocysteine methyltransferase (BHMT), a Zn2+-dependent thiolmethyltransferase, contributes to the regulation of homocysteine levels, increases in which are considered a risk factor for cardiovascular diseases. Most plasma homocysteine is generated through the liver methionine cycle, in which BHMT metabolizes approximately 25% of this non-protein amino acid. This process allows recovery of one of the three methylation equivalents used in phosphatidylcholine synthesis through… CONTINUE READING


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Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver

S. Ratnam, E P.Wijekoon, +3 authors J T.Brosnan
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