Betaine analogues alter homocysteine metabolism in rats.

  title={Betaine analogues alter homocysteine metabolism in rats.},
  author={S. Slow and M. Lever and M. Lee and P. George and S. Chambers},
  journal={The international journal of biochemistry & cell biology},
  volume={36 5},
  • S. Slow, M. Lever, +2 authors S. Chambers
  • Published 2004
  • Chemistry, Medicine
  • The international journal of biochemistry & cell biology
  • Glycine betaine supplementation lowers homocysteine levels in homocystinuria and in chronic renal failure patients through methylation catalysed by betaine-homocysteine methyltransferase (BHMT). The aim of this study was to determine the effect of glycine betaine analogues on homocysteine metabolism in Lewis rats. Glycine betaine, proline betaine, trigonelline, dimethylsulfoniopropionate (DMSP) or dimethylthetin (1.5 mmoles) was subcutaneously administered to rats fed a low betaine diet. The… CONTINUE READING
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