Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet

@article{Du2018BetaineSE,
  title={Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet},
  author={Jingjing Du and Linyuan Shen and Zhendong Tan and Peiwen Zhang and Xue Zhao and Yan Xu and Mailin Gan and Qiong Yang and Jideng Ma and An’an Jiang and Guoqing Tang and Yanzhi Jiang and Long Jin and Mingzhou Li and Lin Bai and Xuewei Li and Jinyong Wang and Shunhua Zhang and Li Zhu},
  journal={Nutrients},
  year={2018},
  volume={10}
}
Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease, certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine is a nontoxic, chemically stable and naturally occurring molecule. This study shows that dietary betaine supplementation significantly inhibits the white fat production in a high-fat diet (HFD)-induced obese mice. This might be due to betaine preventing the formation of new white fat (WAT), and guiding… 

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