Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

@article{Abdelmalek2001BetaineAP,
  title={Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study},
  author={Manal F. Abdelmalek and Paul Angulo and Roberta A. Jorgensen and Pamela B. Sylvestre and Keith D Lindor},
  journal={American Journal of Gastroenterology},
  year={2001},
  volume={96},
  pages={2711-2717}
}
OBJECTIVES:No effective therapy currently exists for patients with nonalcoholic steatohepatitis (NASH). Betaine, a naturally occurring metabolite of choline, has been shown to raise S-adenosylmethionine (SAM) levels that may in turn play a role in decreasing hepatic steatosis. Our aim was to determine the safety and effects of betaine on liver biochemistries and histological markers of disease activity in patients with NASH.METHODS:Ten adult patients with NASH were enrolled. Patients received… CONTINUE READING
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