Betaglycan alters NFκB-TGFβ2 cross talk to reduce survival of human granulosa tumor cells.

@article{Bilandzic2013BetaglycanAN,
  title={Betaglycan alters NFκB-TGFβ2 cross talk to reduce survival of human granulosa tumor cells.},
  author={Maree Bilandzic and Simon Chu and Yao Wang and Han L Tan and Peter J Fuller and John K. Findlay and Kaye L. Stenvers},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 3},
  pages={
          466-79
        }
}
The molecular pathways controlling granulosa cell tumor (GCT) survival are poorly understood. In many cell types, nuclear factor-κB (NFκB) and TGFβ coordinately regulate cell survival to maintain tissue homeostasis. Because GCT cell lines exhibit constitutively activated NFκB, we hypothesized that NFκB blocks TGFβ-mediated cell death in GCT cells. To test this hypothesis, we used the human GCT cell line KGN, which exhibits loss of betaglycan, a TGFβ co-receptor. After inhibition of NFκB in KGN… CONTINUE READING