Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.

@article{GmezGaviro2012BetacellulinPC,
  title={Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.},
  author={Mar{\'i}a Victoria G{\'o}mez-Gaviro and Charlotte E Scott and Abdul K. Sesay and Ander Matheu and S. H. Booth and Christophe Galichet and Robin Lovell-Badge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 4},
  pages={1317-22}
}
Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain, including the subventricular zone and the dentate gyrus, which act to control NSC behavior. Among other cell types within these niches, NSCs are found in close proximity to blood vessels. We carried out an analysis of the interaction between endothelial cells and NSCs, and show that betacellulin (BTC), a member of the EGF family and one of several signaling molecules made by the former, induces NSC proliferation… CONTINUE READING
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